CDK2 degrader 2
CDK2 degrader 2 (Compound I-10) is a PROTAC degrader for CDK2 that degrades CDK2 in MKN1 cell with a DC50 [1]. (Pink: ligand for target protein (HY-176124) ; Black: linker (HY-W687952) ; Blue: ligand for E3 ligase CRBN (HY-45512) )
Product Specifications
CAS Number
[3030271-16-7]
UNSPSC
12352005
Target
CDK; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk2-degrader-2.html
Purity
99.51
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1C(Cl)=CC2=C(N1C(C)C)N=C(NC3=CC=C(S(=O)(C4CCN(C5CCN(CC6CCN(CC6)C7=C(N(C)C(N8C9C(NC(CC9)=O)=O)=O)C8=CC=C7)CC5)CC4)=O)C=C3C)N=C2
Molecular Formula
C46H57ClN10O6S
Molecular Weight
913.53
References & Citations
[1]Philip Collier, et al., Cdk2 degraders and uses thereof. WO2024039901A2
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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