CDK2 degrader 2
Product Specifications
UNSPSC Description
CDK2 degrader 2 is a PROTAC class CDK2 degrader. The CDK2 binding moiety (CBM) binds to the CDK2 protein and subsequently undergoes ubiquitination, leading to the degradation of CDK2 through the ubiquitin proteasome pathway (UPP). CDK2 degrader 2 can cause degradation of CDK2 in MKN1 cells, with a DC50 value less than 100 nM and an average Dmax value greater than 75%. (Red: CBM; Blue: DIM; Black: linker)
Target Antigen
CDK; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/cdk2-degrader-2.html
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1C(Cl)=CC2=C(N1C(C)C)N=C(NC3=CC=C(S(=O)(C4CCN(C5CCN(CC6CCN(CC6)C7=C(N(C)C(N8C9C(NC(CC9)=O)=O)=O)C8=CC=C7)CC5)CC4)=O)C=C3C)N=C2
Molecular Weight
913.53
References & Citations
[1] Collier, Philip, et al. CDK2 DEGRADERS AND USES THEREOF. US, US20240173419A1. 2024-05-30.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163815/CDK2-degrader-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163815/CDK2-degrader-2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
3030271-16-7
Available Sizes
Curated Selection
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