Veludacigib
BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor. BAY 2965501 induces pERK activation. BAY 2965501 can be used for the research of cancer[1].
Product Specifications
CAS Number
2732902-08-6
Product Name Alternative
BAY 2965501
UNSPSC
12352005
Target
DGK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bay-2965501.html
Concentration
10mM
Purity
99.92
Solubility
DMSO : ≥ 100 mg/mL
Smiles
NC([C@@H](C)N(C1=CC=C(C=C1)F)C2=NC(N)=C(C(C3=CC=C(C=C3)OC)=O)S2)=O
Molecular Formula
C20H19FN4O3S
Molecular Weight
414.45
References & Citations
[1]Schubert N, et al. Phosphorylated extracellular signal-regulated kinase (pERK) activation in T effector cells as a target engagement biomarker for the DGKζ inhibitor BAY2965501 in clinical trials. Cancer Research, 2023, 83 (7_Supplement) : 2116-2116.|[2]Rienk Offringa, et al. 926 BAY 2965501: a highly selective DGK zeta inhibitor for cancer immunotherapy. Regular and Young Investigator Award Abstracts. Immune Cell Types and Biology.|[3]Schlicher L, et al. Small molecule inhibitors for cancer immunotherapy and associated biomarkers - the current status. Front Immunol. 2023 Oct 31;14:1297175.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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