(R, S) -Ivosidenib
(R, S) -Ivosidenib ((R, S) -AG-120) is a less active enantiomer of ivosidenib (AG-120) . Ivosidenib can be used in the research of IDH1 mutant cancers[1].
Product Specifications
CAS Number
2070009-31-1
Product Name Alternative
(R, S) -AG-120
UNSPSC
12352005
Hazard Statement
H315, H317, H319, H335
Target
Isocitrate Dehydrogenase (IDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/_R,S_-Ivosidenib.html
Purity
98.49
Solubility
DMSO : 3.33 mg/mL (ultrasonic)
Smiles
FC1(F)CC(NC([C@H](N(C2=CC(F)=CN=C2)C([C@@H](N3C4=NC=CC(C#N)=C4)CCC3=O)=O)C5=CC=CC=C5Cl)=O)C1
Molecular Formula
C28H22ClF3N6O3
Molecular Weight
582.96
Precautions
H315, H317, H319, H335
References & Citations
[1]Popovici-Muller J, et al. Discovery of AG-120 (Ivosidenib) : A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1Mutant Cancers. ACS Med Chem Lett. 2018 Jan 19;9 (4) :300-305.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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