(R, S) -Ivosidenib

(R, S) -Ivosidenib ((R, S) -AG-120) is a less active enantiomer of ivosidenib (AG-120) . Ivosidenib can be used in the research of IDH1 mutant cancers[1].

Product Specifications

CAS Number

[2070009-31-1]

Product Name Alternative

(R, S) -AG-120

UNSPSC

12352005

Hazard Statement

H315, H317, H319, H335

Target

Isocitrate Dehydrogenase (IDH)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/_R,S_-Ivosidenib.html

Purity

98.49

Solubility

DMSO : 3.33 mg/mL (ultrasonic)

Smiles

FC1(F)CC(NC([C@H](N(C2=CC(F)=CN=C2)C([C@@H](N3C4=NC=CC(C#N)=C4)CCC3=O)=O)C5=CC=CC=C5Cl)=O)C1

Molecular Formula

C28H22ClF3N6O3

Molecular Weight

582.96

Precautions

H315, H317, H319, H335

References & Citations

[1]Popovici-Muller J, et al. Discovery of AG-120 (Ivosidenib) : A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1Mutant Cancers. ACS Med Chem Lett. 2018 Jan 19;9 (4) :300-305.