Tasimelteon

Tasimelteon (BMS-214778) is an orally active and selective dual melatonin receptor agonist (DMRA) . Tasimelteon has 2.1-4.4 times greater affinity for the MT2 receptor than for the MT1 receptor. Tasimelteon is a circadian regulator and has the potential for Non-24-Hour Sleep-Wake Disorder (Non-24) [1][2].

Product Specifications

CAS Number

[609799-22-6]

Product Name Alternative

BMS-214778; VEC-162

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Melatonin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Tasimelteon.html

Purity

99.68

Solubility

DMSO : ≥ 33 mg/mL

Smiles

[H][C@]1(C2=C3C(OCC3)=CC=C2)[C@@](CNC(CC)=O)([H])C1

Molecular Formula

C15H19NO2

Molecular Weight

245.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Christian Lavedan, et al. Tasimelteon: a selective and unique receptor binding profile. Neuropharmacology. 2015 Apr;91:142-7.|[2]Keating GM, et al. Tasimelteon: A Review in Non-24-Hour Sleep-Wake Disorder in Totally Blind Individuals. CNS Drugs. 2016 Mar 22.