4-Oxofenretinide
4-Oxofenretinide (4-Oxo-4-HPR) is a metabolite of Fenretinide. 4-Oxofenretinide induces cell growth inhibition in ovarian, breast, and neuroblastoma tumor cell lines. 4-Oxofenretinide causes a marked accumulation of cells in G2-M. 4-Oxofenretinide induces cancer cell apoptosis through caspase-9[1].
Product Specifications
CAS Number
865536-65-8
Product Name Alternative
4-Oxo-4-HPR
UNSPSC
12352005
Hazard Statement
H302+H312+H332, H315, H319, H335, H360
Target
Apoptosis; Drug Metabolite; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/4-oxofenretinide.html
Purity
96.89
Solubility
10 mM in DMSO
Smiles
OC(C=C1)=CC=C1NC(/C=C(C)/C=C/C=C(C)/C=C/C(C(C)(CC2)C)=C(C)C2=O)=O
Molecular Formula
C26H31NO3
Molecular Weight
405.53
Precautions
H302+H312+H332, H315, H319, H335, H360
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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