4-Oxofenretinide

4-Oxofenretinide (4-Oxo-4-HPR) is a metabolite of Fenretinide (HY-15373) . 4-Oxofenretinide induces cell growth inhibition in ovarian, breast, and neuroblastoma tumor cell lines. 4-Oxofenretinide causes a marked accumulation of cells in G2-M. 4-Oxofenretinide induces cancer cell apoptosis through caspase-9[1].

Product Specifications

CAS Number

[865536-65-8]

Product Name Alternative

4-Oxo-4-HPR

UNSPSC

12352005

Hazard Statement

H302+H312+H332, H315, H319, H335, H360

Target

Apoptosis; Drug Metabolite; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/4-oxofenretinide.html

Purity

96.89

Solubility

10 mM in DMSO

Smiles

OC(C=C1)=CC=C1NC(/C=C(C)/C=C/C=C(C)/C=C/C(C(C)(CC2)C)=C(C)C2=O)=O

Molecular Formula

C26H31NO3

Molecular Weight

405.53

Precautions

H302+H312+H332, H315, H319, H335, H360

References & Citations

[1]Villani MG, et al. 4-oxo-fenretinide, a recently identified fenretinide metabolite, induces marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitive and fenretinide-resistant cell lines. Cancer Res. 2006 Mar 15;66 (6) :3238-47.|[2]Villani MG, et al. 4-oxo-fenretinide, a recently identified fenretinide metabolite, induces marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitive and fenretinide-resistant cell lines. Cancer Res. 2006 Mar 15;66 (6) :3238-47.