Substance P (3-11)

Substance P (3-11) is a substance P (SP) fragment peptide that can cross the BBB. Substance P (3-11) has contracting activities on guinea pig ileum. Substance P (3-11) also promotes human monocyte chemotaxis [1][2][5].

Product Specifications

CAS Number

[51165-11-8]

UNSPSC

12352209

Target

Neurokinin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/substance-p-3-11.html

Solubility

10 mM in DMSO

Smiles

O=C(N1[C@@H](CCC1)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC3=CC=CC=C3)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(N)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N

Molecular Formula

C52H79N13O11S

Molecular Weight

1094.33

References & Citations

[1]Yanaihara N, et al. Immunological aspects of secretin, substance P, and VIP. Gastroenterology. 1977 Apr;72 (4 Pt.2) :803-10. |[2]Chappa AK, et al. Characteristics of substance P transport across the blood-brain barrier. Pharm Res. 2006 Jun;23 (6) :1201-8. |[3]Ruff MR, et al. Substance P receptor-mediated chemotaxis of human monocytes. Peptides. 1985;6 Suppl 2:107-11. |[4]Sertl K, et al. Substance P: the relationship between receptor distribution in rat lung and the capacity of substance P to stimulate vascular permeability. Am Rev Respir Dis. 1988 Jul;138 (1) :151-9. |[5]Freed AL, et al. Investigation of substance P transport across the blood-brain barrier. Peptides. 2002 Jan;23 (1) :157-65.