CGP60474
CGP60474, a highly potent anti-endotoxemic agent, is a potent cyclin-dependent kinase (CDK) inhibitor (IC50 values are 26, 3, 4, 216, 10, 200 and 13 nM for CDK1/B, CDK2/E, CDK2/A, CDK4/D, CDK5/p25, CDK7/H and CDK9/T, respectively) . CGP60474 is a selective and ATP-competitive PKC inhibitor[1][2][3].
Product Specifications
CAS Number
164658-13-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CDK; PKC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CGP60474.html
Purity
98.90
Solubility
DMSO : ≥ 50 mg/mL
Smiles
ClC1=CC(NC2=NC=CC(C3=CC=NC(NCCCO)=C3)=N2)=CC=C1
Molecular Formula
C18H18ClN5O
Molecular Weight
355.82
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK2; CDK4; CDK5; CDK7; CDK9; PKC
Available Sizes
Frequently Asked Questions
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