Chk1-IN-6

Chk1-IN-6 is a selective and orally active Chk1 inhibitor with an IC50 of 16.1 nM. Chk1-IN-6 shows antiproliferative activity of MV-4-11 cells. Chk1-IN-6 exerts effective response in the MV-4-11 xenograft mouse model. Chk1-IN-6 exhibits synergistic anticancer effect with Gemcitabine (HY-17026) . Chk1-IN-6 can be used in the research of cancers such as acute myeloid leukemia and colorectal adenocarcinoma[1].

Product Specifications

CAS Number

[2428423-77-0]

UNSPSC

12352005

Target

Checkpoint Kinase (Chk)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/chk1-in-6.html

Purity

98.39

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

N#CC(C=C1)=NC=C1NC2=NC=C(C(F)(F)F)C(NCCC(C)(C)N)=N2

Molecular Formula

C16H18F3N7

Molecular Weight

365.36

References & Citations

[1]Jin T, et al. Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5- ((4- ((3-Amino-3-methylbutyl) amino) -5- (trifluoromethyl) pyrimidin-2-yl) amino) picolinonitrile. J Med Chem. 2021 Oct 28;64 (20) :15069-15090.