MGH-CP1

MGH-CP1 is a potent and orally active TEAD2 and TEAD4 auto-palmitoylation inhibitor with IC50s of 710 nM and 672 nM, respectively. MGH-CP1 can decrease the palmitoylation levels of endogenous or ectopically expressed TEAD proteins in cells. MGH-CP1 can suppress Myc expression, inhibit epithelial over-proliferation, and induce apoptosis when together with Lats1/2 deletion[1].

Product Specifications

CAS Number

[896657-58-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mgh-cp1.html

Concentration

10mM

Purity

99.56

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CSC1=NN=CN1)NC2=CC=C(C=C2)C3(C[C@H](C4)C5)C[C@H]5C[C@H]4C3

Molecular Formula

C20H24N4OS

Molecular Weight

368.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Li Q, Sun Y, Jarugumilli GK, et al. Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription. Cell Stem Cell. 2020;26 (5) :675-692.e8. doi:10.1016/j.stem.2020.03.002