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Trichostatin C

Trichostatin C is an inhibitor for histone deacetylase (HDAC), induces apoptosis and arrests cell cycle at G2/M phase, and exhibits anticancer activity against lung cancer and urothelial bladder cancer[1]. Trichostatin C induces differentation of Friend leukemic cells[2]. Trichostatin C exhibits antifungal activity[3].

Product Specifications

CAS Number

68676-88-0

UNSPSC

12352005

Target

Apoptosis; Fungal; HDAC

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/trichostatin-c.html

Solubility

10 mM in DMSO

Smiles

O=C(NO[C@H]1[C@@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)O)/C=C/C(C)=C/[C@@H](C)C(C2=CC=C(N(C)C)C=C2)=O

Molecular Formula

C23H32N2O8

Molecular Weight

464.51

References & Citations

[1]Wang C, et al., Trichostatin C Synergistically Interacts with DNMT Inhibitor to Induce Antineoplastic Effect via Inhibition of Axl in Bladder and Lung Cancer Cells[J]. Pharmaceuticals, 2024, 17 (4) : 425.|[2]Yoshida M, et al., Trichostatin C, a new inducer of differentiation of Friend leukemic cells[J]. Agricultural and biological chemistry, 1985, 49 (2) : 563-565.|[3]Tsuji N, et al., a glucopyranosyl hydroxamate. J Antibiot (Tokyo) . 1978 Oct;31 (10) :939-44.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HDAC1; HDAC6

Frequently Asked Questions

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