Squarunkin A
Squarunkin A is a potent and selective UNC119-cargo interaction inhibitor, interrupting the UNC119A-myristoylated Src N-terminal peptide interaction (IC50=10 nM) . Squarunkin A interferes with the activation of Src kinase in cells[1].
Product Specifications
CAS Number
[2101958-02-3]
UNSPSC
12352005
Target
Src
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/squarunkin-a.html
Purity
99.49
Solubility
DMSO : 9.62 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N1CCC(NC2=C(NCCN3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3)C(C2=O)=O)CC1)OCC
Molecular Formula
C25H32F3N5O4
Molecular Weight
523.55
References & Citations
[1]Tom Mejuch, et al. Small-Molecule Inhibition of the UNC119-Cargo Interaction. Angew Chem Int Ed Engl. 2017 May 22;56 (22) :6181-6186.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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