Indotecan (hydrochloride)

Indotecan hydrochloride, an indenoisoquinoline derivative, is a potent Topoisomerase I inhibitor, with IC50s of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan hydrochloride prevents the relaxation of supercoiled DNA and can be used for the research of visceral leishmaniasis[1][2].

Product Specifications

CAS Number

[1228035-68-4]

Product Name Alternative

LMP-400 (hydrochloride) ; NSC-724998 (hydrochloride)

UNSPSC

12352005

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/indotecan-hydrochloride.html

Purity

99.80

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=C(C3=C1C4=CC(OC)=C(C=C4C(N3CCCN5CCOCC5)=O)OC)C=C6OCOC6=C2.Cl

Molecular Formula

C26H27ClN2O7

Molecular Weight

514.95

References & Citations

[1]Balaña-Fouce R, et, al. Indotecan (LMP400) and AM13-55: two novel indenoisoquinolines show potential for treating visceral leishmaniasis. Antimicrob Agents Chemother. 2012 Oct;56 (10) :5264-70.|[2]Seol Y, et, al. Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors. Mol Cancer Ther. 2015 Nov;14 (11) :2552-9.