BJJF078
Product Specifications
UNSPSC Description
BJJF078 is an aminopiperidine derivative. BJJF078 is a potent inhibitor of recombinant human and mouse Transglutaminase enzyme (TG2) activity, IC50 values of 41 and 54 nM, respectively. BJJF078 also inhibits the close related enzyme TG1, with an IC50 of 0.16 μM. BJJF078 can be used for Multiple sclerosis (MS) research[1].
Target Antigen
Glutaminase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bjjf078.html
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NC1CCN(S(=O)(C2=C3C=CC=C(NC(C4=CC=C(C(OC)=C4)OC)=O)C3=CC=C2)=O)CC1)C=C
Molecular Weight
523.60
References & Citations
[1]Chrobok NL, et al. Characterization of Transglutaminase 2 activity inhibitors in monocytes in vitro and their effect in a mouse model for multiple sclerosis. PLoS One. 2018 Apr 24;13(4):e0196433.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145933/BJJF078-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145933/BJJF078-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2531244-56-9
Available Sizes
Curated Selection
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