FAK-IN-2
FAK-IN-2 is a potent and orally active focal adhesion kinase (FAK) inhibitor, with anticancer activity (FAK IC50= 35 nM) . FAK-IN-2 covalently inhibits the autophosphorylation of FAK in a dose-dependent manner, and inhibits the clone formation and migration of tumor cells, inducing apoptosis[1].
Product Specifications
CAS Number
[2872588-02-6]
UNSPSC
12352005
Target
Apoptosis; FAK
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fak-in-2.html
Purity
98.27
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C=CC(N[C@@H](C(N1CCN(CC1)C2=CC=C(C=C2)NC3=NC(NC4=C(C=CC=C4)C(NC)=O)=C(C=N3)Cl)=O)C)=O
Molecular Formula
C28H31ClN8O3
Molecular Weight
563.05
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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