What is the catalog number for CHZ868?

The catalog number for CHZ868 is HY-18960.

What sizes are available for CHZ868?

CHZ868 is available in the following size(s): 5 mg, 10 mM - 1 mL, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg, 1 g.

How many pack sizes does CHZ868 come in?

CHZ868 is available in 8 different pack sizes.

CHZ868 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures CHZ868?

CHZ868 is manufactured by QuantiMol.

What is the estimated delivery time for CHZ868?

Estimated delivery time for CHZ868 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for CHZ868?

The safety data sheet for CHZ868 is available here: http://file.medchemexpress.com/batch_PDF/HY-18960/CHZ868-SDS-MedChemExpress.pdf.

CHZ868

CHZ868 is a type II JAK2 inhibitor with an IC50 of 0.17 μM in EPOR JAK2 WT Ba/F3 cell.

Product Specifications

CAS Number

1895895-38-1

UNSPSC

12352005

Hazard Statement

H315, H317, H318, H334, H335, H341, H361, H370, H413

Target

JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CHZ868.html

Purity

99.38

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(NC1=CC(OC2=CC=C(N(C)C(NC3=CC=C(F)C=C3F)=N4)C4=C2C)=CC=N1)=O

Molecular Formula

C22H19F2N5O2

Molecular Weight

423.42

Precautions

H315, H317, H318, H334, H335, H341, H361, H370, H413

References & Citations

[1]Meyer SC, et al. CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms. Cancer Cell. 2015 Jul 13;28 (1) :15-28.|[2]Wu SC, et al. Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia. Cancer Cell. 2015 Jul 13;28 (1) :29-41.