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UCD38B (hydrochloride)

UCD38B hydrochloride is a cell permeant, competitive enzymatic uPA inhibitor with an IC50 value of 7 μM. UCD38B hydrochloride targets intracellular uPA causing mistrafficking of uPA into perinuclear mitochondria, reducing the mitochondrial membrane potential, and followed by the release of apoptotic inducible factor (AIF) . UCD38B hydrochloride induces apoptosis[1][2].

Product Specifications

CAS Number

1115177-19-9

Product Name Alternative

γDGG; γ-D-Glutamylglycine,γDGG (acetate); γ-D-Glutamylglycine (acetate)

UNSPSC

12352005

Target

Apoptosis; PAI-1

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ucd38b-hydrochloride.html

Purity

99.31

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CNC1=C(Cl)N=C(C(NC(N)=N)=O)C(N)=N1)OCC2=CC=CC=C2.Cl.[x]

Molecular Formula

C15H16ClN7O3.xHCl

References & Citations

[1]Pasupuleti N, et, al. 5-Benzylglycinyl-amiloride kills proliferating and nonproliferating malignant glioma cells through caspase-independent necroptosis mediated by apoptosis-inducing factor. J Pharmacol Exp Ther. 2013 Mar;344 (3) :600-15.|[2]Leon LJ, et, al. A cell-permeant amiloride derivative induces caspase-independent, AIF-mediated programmed necrotic death of breast cancer cells. PLoS One. 2013 Apr 30;8 (4) :e63038.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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