Kokusaginine

Kokusaginine is a furoquinoline alkaloids, which exhibits inhibitory efficacy for acetylcholinesterase (AChE) with an IC50 of 28.2 μM. Kokusaginine exhibits anti-proliferative and apoptotic inducing effects in MCF-7/ADR cells[1][2].

Product Specifications

CAS Number

[484-08-2]

UNSPSC

12352005

Target

Apoptosis; Cholinesterase (ChE) ; Microtubule/Tubulin

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/kokusaginine.html

Purity

Solubility

10 mM in DMSO

Smiles

COC1=C(C=C2C(OC)=C3C(OC=C3)=NC2=C1)OC

Molecular Formula

C14H13NO4

Molecular Weight

259.26

References & Citations

[1]Sichaem J, et al., Furoquinoline Alkaloids from the Leaves of Evodia lepta as Potential Cholinesterase Inhibitors and their Molecular Docking. Nat Prod Commun. 2015 Aug;10 (8) :1359-62.|[2]Chen H, et al., The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. Bioorg Med Chem Lett. 2018 Aug 1;28 (14) :2490-2492.