Kokusaginine
Kokusaginine is a furoquinoline alkaloids, which exhibits inhibitory efficacy for acetylcholinesterase (AChE) with an IC50 of 28.2 μM. Kokusaginine exhibits anti-proliferative and apoptotic inducing effects in MCF-7/ADR cells[1][2].
Product Specifications
CAS Number
[484-08-2]
UNSPSC
12352005
Target
Apoptosis; Cholinesterase (ChE) ; Microtubule/Tubulin
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/kokusaginine.html
Purity
98
Solubility
10 mM in DMSO
Smiles
COC1=C(C=C2C(OC)=C3C(OC=C3)=NC2=C1)OC
Molecular Formula
C14H13NO4
Molecular Weight
259.26
References & Citations
[1]Sichaem J, et al., Furoquinoline Alkaloids from the Leaves of Evodia lepta as Potential Cholinesterase Inhibitors and their Molecular Docking. Nat Prod Commun. 2015 Aug;10 (8) :1359-62.|[2]Chen H, et al., The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. Bioorg Med Chem Lett. 2018 Aug 1;28 (14) :2490-2492.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
AChE
Available Sizes
Curated Selection
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