TbPTR1 inhibitor 2
TbPTR1 inhibitor 2 (Compound 3a) is a PTR1 enzyme inhibitor, with IC50s of 34.2 and 32.9 μM for TbPTR1 and LmPTR1. TbPTR1 inhibitor 2 has anti-parasitic activity against T. brucei (IC50: 34.2 μM) [1].
Product Specifications
CAS Number
17557-67-4
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/tbptr1-inhibitor-2.html
Purity
99.73
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
NC1=NC2=CC=C(S(=O)(C)=O)C=C2S1
Molecular Formula
C8H8N2O2S2
Molecular Weight
228.30
Precautions
H301, H315, H319, H335
References & Citations
[1]Linciano P, et al. Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. J Med Chem. 2019 Apr 25;62 (8) :3989-4012.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC471820-500 1x 500 µL
Ep-CAM / CD326 (Epithelial Marker) (rVU-1D9), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470270-500 1x 500 µL
Fibronectin (HFN7.1), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC880687-100 1x 100 µL
Cytokeratin 8 (H1 + TS1), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC881660-500 1x 500 µL
Cytokeratin 1 (Suprabasal Keratinocyte Marker) (LHK1), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470994-500 1x 500 µL
TNF alpha (J2D10), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC941602-100 1x 100 µL
CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (ERIC-1), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details