TbPTR1 inhibitor 2
TbPTR1 inhibitor 2 (Compound 3a) is a PTR1 enzyme inhibitor, with IC50s of 34.2 and 32.9 μM for TbPTR1 and LmPTR1. TbPTR1 inhibitor 2 has anti-parasitic activity against T. brucei (IC50: 34.2 μM) [1].
Product Specifications
CAS Number
[17557-67-4]
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/tbptr1-inhibitor-2.html
Purity
99.73
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
NC1=NC2=CC=C(S(=O)(C)=O)C=C2S1
Molecular Formula
C8H8N2O2S2
Molecular Weight
228.30
Precautions
H301, H315, H319, H335
References & Citations
[1]Linciano P, et al. Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. J Med Chem. 2019 Apr 25;62 (8) :3989-4012.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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