Macelignan

Macelignan ((+) -Anwulignan; Anwuligan) is an orally active lignan isolated from Myristica fragrans. Macelignan possesses many pharmacological activities, including anti-inflammatory, anti-cancer, anti-diabetes, and neuroprotective activities[1][2][3].

Product Specifications

CAS Number

[107534-93-0]

Product Name Alternative

(+) -Anwulignan; Anwuligan

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

COX

Type

Natural Products

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Macelignan.html

Purity

99.85

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C[C@H](C)[C@H](C)CC2=CC=C(OCO3)C3=C2)C=C1OC

Molecular Formula

C20H24O4

Molecular Weight

328.40

Precautions

H302, H315, H319

References & Citations

[1]Anggakusuma, et al. Effects of macelignan isolated from Myristica fragrans Houtt. on UVB-induced matrix metalloproteinase-9 and cyclooxygenase-2 in HaCaT cells. J Dermatol Sci|[2]Jiyoung Yeo, et al. Effects of a multi-herbal extract on type 2 diabetes. Chin Med. 2011 Mar 4;6:10.|[3]Chun-Ai Cui, et al. Macelignan attenuates LPS-induced inflammation and reduces LPS-induced spatial learning impairments in rats. Neurosci Lett. 2008 Dec 19;448 (1) :110-4.