(+) -JQ1 (Highly Pure)

<strong>(+)-JQ1 (Highly Pure)</strong>_x000D_ <strong>Catalog number:</strong> B2019163_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 5 mg_x000D_ <strong>Molecular Weight or Concentration:</strong> 457.0 Da_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> 2-8°C_x000D_ <strong>Keywords:</strong> BET inhibitor, Bromodomain inhibitor_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Wang L, Xu M, Kao CY, Tsai SY, Tsai MJ. Small molecule JQ1 promotes prostate cancer invasion via BET-independent inactivation of FOXA1 J Clin Invest. 2020 Apr 1;130(4):1782-1792._x000D_ 2: Shi X, Liu C, Liu B, Chen J, Wu X, Gong W. JQ1: a novel potential therapeutic target Pharmazie. 2018 Sep 1;73(9):491-493._x000D_ 3: Babigian CJ, Wiedner HJ, Wahlestedt C, Sartor GC. JQ1 attenuates psychostimulant- but not opioid-induced conditioned place preference Behav Brain Res. 2022 Feb 10;418:113644._x000D_ 4: Zhong X, Chen Z, Wang Y, Mao M, Deng Y, Shi M, Xu Y, Chen L, Cao W. JQ1 attenuates neuroinflammation by inhibiting the inflammasome-dependent canonical pyroptosis pathway in SAE Brain Res Bull. 2022 Oct 15;189:174-183._x000D_ 5: De S, Sahu R, Palei S, Narayan Nanda L. Synthesis, SAR, and application of JQ1 analogs as PROTACs for cancer therapy Bioorg Med Chem. 2024 Oct 1;112:117875._x000D_ 6: Fornelli C, Sofia Cento A, Nevi L, Mastrocola R, Ferreira Alves G, Caretti G, Collino M, Penna F. The BET inhibitor JQ1 targets fat metabolism and counteracts obesity J Adv Res. 2024 Feb 15:S2090-1232(24)00051-1._x000D_ 7: Chen X, Jiang Q, Ren L, Ren H, Xu H, Wang J, Wang P, Chen S, Hua Y, Ren S, Huang N, Zhang L, Xiao L. BET proteins inhibitor JQ1 impairs GM-CSF-promoted peritoneal macrophage self-renewal and IL-4-induced alternative polarization Int Immunopharmacol. 2023 Nov;124(Pt A):110942._x000D_ 8: Marchant V, Trionfetti F, Tejedor-Santamaria L, Rayego-Mateos S, Rotili D, Bontempi G, Domenici A, Menè P, Mai A, Martín-Cleary C, Ortiz A, Ramos AM, Strippoli R, Ruiz-Ortega M. BET Protein Inhibitor JQ1 Ameliorates Experimental Peritoneal Damage by Inhibition of Inflammation and Oxidative Stress Antioxidants (Basel). 2023 Nov 29;12(12):2055._x000D_ 9: Go S, Kang M, Kwon SP, Jung M, Jeon OH, Kim BS. The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis Tissue Eng Regen Med. 2021 Oct;18(5):841-850._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/36654036">10: Zhu Y, Guo L, Zou J, Wang L, Dong H, Yu S, Zhang L, Li J, Qu X. JQ1 inhibits high glucose-induced migration of retinal microglial cells by regulating the PI3K/AKT signaling pathway Math Biosci Eng. 2022 Sep 6;19(12):13079-13092. </a>_x000D_ _x000D_ <strong>Products Related to (+)-JQ1 (Highly Pure) can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>