PROTAC SMARCA2 degrader-7
PROTAC SMARCA2 degrader-7 (Compound I-428) is a PROTAC degrader for SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A (SMARCA) SMARCA2. PROTAC SMARCA2 degrader-7 degrades SMARCA2 and SMARCA4 in MV411 with DC50 of [1]
Product Specifications
CAS Number
[2568277-71-2]
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-smarca2-degrader-7.html
Smiles
O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)[C@H](C(C)(C)C)NC(C(CC4)(CC5)CCC45CN6CCC(N7C=C(C8=C(N)N=NC(C9=C(C=CC=C9)O)=C8)C=N7)CC6)=O
Molecular Formula
C50H62N10O5S
Molecular Weight
915.16
References & Citations
[1]Ji N, et al., Smarca degraders and uses thereof. US20230072658A1
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Separase, phosphorylated (Ser1176) (ESPL1, Separin, Caspase-like Protein ESPL1, Extra Spindle Poles-like 1 Protein, ESP1, KIAA0165) (APC) discontinued