PROTAC SMARCA2 degrader-7
Product Specifications
UNSPSC Description
PROTAC SMARCA2 degrader-7 (Compound I-428) is a PROTAC degrader for SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A (SMARCA) SMARCA2. PROTAC SMARCA2 degrader-7 degrades SMARCA2 and SMARCA4 in MV411 with DC50 of [1]
Target Antigen
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-smarca2-degrader-7.html
Smiles
O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)[C@H](C(C)(C)C)NC(C(CC4)(CC5)CCC45CN6CCC(N7C=C(C8=C(N)N=NC(C9=C(C=CC=C9)O)=C8)C=N7)CC6)=O
Molecular Weight
915.16
References & Citations
[1]Ji N, et al., Smarca degraders and uses thereof. US20230072658A1
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-159451/PROTAC-SMARCA2-degrader-7-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-159451/
Clinical Information
No Development Reported
CAS Number
2568277-71-2
Curated Selection
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