Chlormethiazole hydrochloride

Clomethiazole hydrochloride is a potent and orally active GABAA agonist[1]. Clomethiazole hydrochloride inhibits cytochrome P450 isoforms: CYP2A6 and CYP2E1 in human liver microsomes. Clomethiazole hydrochloride is an anticonvulsant agent and has the potential for treating convulsive status epilepticus[2].

Product Specifications

CAS Number

[6001-74-7]

Product Name Alternative

Clomethiazole hydrochloride

UNSPSC

12352005

Hazard Statement

H302, H317, H318

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/chlormethiazole-hydrochloride.html

Purity

99.94

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

CC1=C(CCCl)SC=N1.Cl

Molecular Formula

C6H9Cl2NS

Molecular Weight

198.11

Precautions

H302, H317, H318

References & Citations

[1]Hewitt KE, et al. Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA ('Ecstasy') to rats. Neuropharmacology. 1994 Dec;33 (12) :1589-95.|[2]Cross AJ, et al. The protective action of chlormethiazole against ischaemia-induced neurodegeneration in gerbils when infused at doses having little sedative or anticonvulsant activity. Br J Pharmacol. 1995 Apr;114 (8) :1625-30.|[3]Hohmann N, et al. Clomethiazole inhibits cytochrome P450 2E1 and improves alcoholic liver disease. Gut. 2022 Apr;71 (4) :842-844.