Neratinib (maleate)

Neratinib (HKI-272) maleate is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC50s of 59 nM and 92 nM, respectively[1].

Product Specifications

CAS Number

[915942-22-2]

Product Name Alternative

HKI-272 (maleate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/neratinib-maleate.html

Purity

99.74

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

OC(/C=C\C(O)=O)=O.CCOC(C(NC(/C=C/CN(C)C)=O)=C1)=CC2=C1C(NC3=CC(Cl)=C(C=C3)OCC4=CC=CC=N4)=C(C#N)C=N2

Molecular Formula

C34H33ClN6O7

Molecular Weight

673.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Rabindran SK, et al. Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res, 2004, 64 (11), 3958-3965.