Deoxynybomycin
Product Specifications
UNSPSC Description
Deoxynybomycin is an antibiotic, that can be isolated from Streptomyces, and antibacterial activity against Staphylococcus aureus. Deoxynybomycin is the inhibitor for DNA gyrase and Topoisomerase I. Deoxynybomycin induces expression of p21/WAF1, exhibits cytotoxicity and induces apoptosis in cancer cells Saos-2, TMK-1, and THP-1[1][2].
Target Antigen
Antibiotic; Apoptosis; Bacterial; DNA/RNA Synthesis; Topoisomerase
Type
Reference compound
Related Pathways
Anti-infection;Apoptosis;Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/deoxynybomycin.html
Smiles
O=C(N1COC2=C1C3=CC(C(C)=CC4=O)=C2N4C)C=C3C
Molecular Weight
282.29
References & Citations
[1]Parkinson EI, et al., Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteria. Nat Commun. 2015 Apr 24;6:6947.|[2]Egawa K, et al., Deoxynybomycin is a selective anti-tumor agent inducing apoptosis and inhibiting topoisomerase I. Biol Pharm Bull. 2000 Sep;23(9):1036-40.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-116926/Deoxynybomycin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-116926/
Clinical Information
No Development Reported
CAS Number
27259-98-9
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