Deoxynybomycin

Deoxynybomycin is an antibiotic, that can be isolated from Streptomyces, and antibacterial activity against Staphylococcus aureus. Deoxynybomycin is the inhibitor for DNA gyrase and Topoisomerase I. Deoxynybomycin induces expression of p21/WAF1, exhibits cytotoxicity and induces apoptosis in cancer cells Saos-2, TMK-1, and THP-1[1][2].

Product Specifications

CAS Number

[27259-98-9]

UNSPSC

12352005

Target

Antibiotic; Apoptosis; Bacterial; DNA/RNA Synthesis; Topoisomerase

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/deoxynybomycin.html

Smiles

O=C(N1COC2=C1C3=CC(C(C)=CC4=O)=C2N4C)C=C3C

Molecular Formula

C16H14N2O3

Molecular Weight

282.29

References & Citations

[1]Parkinson EI, et al., Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteria. Nat Commun. 2015 Apr 24;6:6947.|[2]Egawa K, et al., Deoxynybomycin is a selective anti-tumor agent inducing apoptosis and inhibiting topoisomerase I. Biol Pharm Bull. 2000 Sep;23 (9) :1036-40.