Camonsertib
Camonsertib (RP-3500) is an orally active, selective ATR kinase inhibitor (ATRi) with an IC50 of 1.00 nM in biochemical assays. Camonsertib shows 30-fold selectivity for ATR over mTOR (IC50=120 nM) and >2,000-fold selectivity over ATM, DNA-PK, and PI3Kα kinases. Camonsertib has potent antitumor activity[1].
Product Specifications
CAS Number
2417489-10-0
Product Name Alternative
RP-3500; ATR inhibitor 4
UNSPSC
12352005
Target
ATM/ATR; mTOR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/camonsertib.html
Purity
99.99
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O[C@@]1(C[C@H]2O[C@H](CC2)C1)C3=C4C(N(C5=NNC=C5)N=C4)=NC(N6[C@@H](COCC6)C)=C3
Molecular Formula
C21H26N6O3
Molecular Weight
410.47
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
ATM; ATR; mTOR
Available Sizes
Frequently Asked Questions
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