Pagoclone
Pagoclone is an active (+) -enantiomer of the racemate RP 59037. Pagoclone is a partial GABA (A) receptor agonist used for the treatment of panic and anxiety disorders.
Product Specifications
CAS Number
133737-32-3
Product Name Alternative
(+) -RP-59037; IP-456; RP-62955
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Pagoclone.html
Purity
98.0
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
O=C1N(C2=NC3=NC(Cl)=CC=C3C=C2)C(CC(CCC(C)C)=O)C4=C1C=CC=C4
Molecular Formula
C23H22ClN3O2
Molecular Weight
407.89
Precautions
H302, H315, H319, H335
References & Citations
[1]Atack JR, et al. The in vivo properties of pagoclone in rat are most likely mediated by 5'-hydroxy pagoclone. Neuropharmacology. 2006 May;50 (6) :677-89.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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