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OSBPL7-IN-1

OSBPL7-IN-1 is an orally active oxysterol binding protein like 7 (OSBPL7) inhibitor. OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1].

Product Specifications

CAS Number

1269826-44-9

UNSPSC

12352005

Target

Apolipoprotein; Oxysterol-binding Protein-related Protein (ORP)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/osbpl7-in-1.html

Purity

99.84

Solubility

DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C)

Smiles

FC(F)(F)COC1=C(C2=CC(Cl)=C(C=C2)Cl)C=C(C=N1)C(N[C@H]3[C@@H](CCCC3)O)=O

Molecular Formula

C20H19Cl2F3N2O3

Molecular Weight

463.28

References & Citations

[1]Matthew B Wright, et al. Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease. Nat Commun. 2021 Aug 2;12 (1) :4662.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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