OSBPL7-IN-1
OSBPL7-IN-1 is an orally active oxysterol binding protein like 7 (OSBPL7) inhibitor. OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1].
Product Specifications
CAS Number
1269826-44-9
UNSPSC
12352005
Target
Apolipoprotein; Oxysterol-binding Protein-related Protein (ORP)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/osbpl7-in-1.html
Purity
99.84
Solubility
DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
FC(F)(F)COC1=C(C2=CC(Cl)=C(C=C2)Cl)C=C(C=N1)C(N[C@H]3[C@@H](CCCC3)O)=O
Molecular Formula
C20H19Cl2F3N2O3
Molecular Weight
463.28
References & Citations
[1]Matthew B Wright, et al. Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease. Nat Commun. 2021 Aug 2;12 (1) :4662.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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