Aftin-5

Aftin-5 is an inducer for Amyloid-β 42 (Aβ42) . Aftin-5 upregulates Aβ42 and downregulates Aβ38 levels in a β-secretase- and γ-secretase-dependent manner by altering the ultrastructure of mitochondria. Aftin-5 exhibits slightly cytotoxicity in cell SH-SY5Y, HT22, N2a and N2a-AβPP695, with IC50s of 180, 194, 178 and 150 μM, respectively[1].

Product Specifications

CAS Number

[1461717-05-4]

UNSPSC

12352005

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/aftin-5.html

Purity

99.70

Solubility

DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC[C@H](CO)NC1=NC(N(C2=CC=CC=C2)C)=C3N=CN(C3=N1)C(C)C

Molecular Formula

C19H26N6O

Molecular Weight

354.45

References & Citations

[1]Hochard A, et al., Aftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease? J Alzheimers Dis. 2013;35 (1) :107-20.