Ro24-7429
Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects[1][2].
Product Specifications
CAS Number
139339-45-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; HIV
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ro24-7429.html
Concentration
10mM
Purity
99.85
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
CNC1=NC2=CC=C(Cl)C=C2C(C3=CC=CN3)=NC1
Molecular Formula
C14H13ClN4
Molecular Weight
272.73
Precautions
H302, H315, H319, H335
References & Citations
[1]A H Patki, et al. HIV-1 Tat protein and its inhibitor Ro 24-7429 inhibit lymphocyte proliferation and induce apoptosis in peripheral blood mononuclear cells from healthy donors. Cell Immunol. 1996 Apr 10;169 (1) :40-6.|[2]Michael O'Hare, et al. Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators. Am J Pathol. 2021 Jul;191 (7) :1193-1208.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1
Available Sizes
Frequently Asked Questions
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