Ro24-7429

Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects[1][2].

Product Specifications

CAS Number

[139339-45-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; HIV

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ro24-7429.html

Concentration

10mM

Purity

99.85

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

CNC1=NC2=CC=C(Cl)C=C2C(C3=CC=CN3)=NC1

Molecular Formula

C14H13ClN4

Molecular Weight

272.73

Precautions

H302, H315, H319, H335

References & Citations

[1]A H Patki, et al. HIV-1 Tat protein and its inhibitor Ro 24-7429 inhibit lymphocyte proliferation and induce apoptosis in peripheral blood mononuclear cells from healthy donors. Cell Immunol. 1996 Apr 10;169 (1) :40-6.|[2]Michael O'Hare, et al. Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators. Am J Pathol. 2021 Jul;191 (7) :1193-1208.