NecroIr1

NecroIr1 is an iridium (III) complex, serves as necroptosis inducers in Cisplatin (HY-17394) -resistant lung cancer cells (A549R) . NecroIr1 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential (MMP) . NecroIr1 activates receptor-interacting serine-threonine kinase 3 (RIPK3) and Mixed Lineage Kinase (MLKL), and regulates CDK4 expression[1].

Product Specifications

UNSPSC

12352300

Target

CDK; Mixed Lineage Kinase; RIP kinase

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/necroir1.html

Concentration

10mM

Purity

98.02

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=CC(C2=[N]3C=CC(C4=NC(C=CC=C5)=C5O4)=C2)=[N]([Ir]67([N]8=CC=CC=C8C9=C7C=CC=C9)3[N]%10=CC=CC=C%10C%11=C6C=CC=C%11)C=C1.[Cl-]

Molecular Formula

C40H29ClIrN5O

Molecular Weight

823.36

References & Citations

[1]Guan R, et al. Necroptosis-inducing iridium (III) complexes as regulators of cyclin-dependent kinases[J]. Inorganic Chemistry Frontiers, 2021, 8 (7) : 1788-1794.