Tannic acid

Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM.

Product Specifications

CAS Number

[1401-55-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Potassium Channel

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Tannic_acid.html

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

O=C(C1=CC(OC(C2=CC(O)=C(O)C(O)=C2)=O)=C(O)C(O)=C1)OC3[C@H](OC(C4=CC(OC(C5=CC(O)=C(O)C(O)=C5)=O)=C(O)C(O)=C4)=O)[C@@H](OC(C6=CC(OC(C7=CC(O)=C(O)C(O)=C7)=O)=C(O)C(O)=C6)=O)[C@H](OC(C8=CC(OC(C9=CC(O)=C(O)C(O)=C9)=O)=C(O)C(O)=C8)=O)[C@@H](COC(C%10=CC(OC(C%11=CC(O)=C(O)C(O)=C%11)=O)=C(O)C(O)=C%10)=O)O3

Molecular Formula

C76H52O46

Molecular Weight

1701.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Xi Chu, et al. Effects of Tannic Acid, Green Tea and Red Wine on hERG Channels Expressed in HEK293 Cells. PLoS One. 2015; 10 (12) : e0143797.|[2]Karuppagounder V, et al. Tannic acid modulates NFκB signaling pathway and skin inflammation in NC/Nga mice through PPARγ expression. Cytokine. 2015 Dec;76 (2) :206-13.