LysoSensor PDMPO

PDMPO, a lysosome pH indicator, is an excellent fluorescent acidotropic reagent for fluorescence imaging. PDMPO is a potent tool with which to study acidic organelles of live cells. PDMPO exhibits pH-dependent dual-excitation and dual-emission spectral peaks. PDMPO produces a blue fluorescence in weakly acidic organelles and shifts to yellow in more acidic lysosomes. (Abs=329 nm; Em=440/540 nm) [1].

Product Specifications

UNSPSC

12171500

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/lysosensor-pdmpo.html

Purity

98.77

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(NCCN(C)C)COC(C=C1)=CC=C1C2=CN=C(O2)C3=CC=NC=C3

Molecular Formula

C20H22N4O3

Molecular Weight

366.41

References & Citations

[1]L V Albrecht, et al. Protocol for Probing Regulated Lysosomal Activity and Function in Living Cells. STAR Protoc. 2020 Oct 17;1 (3) :100132.|[2]Patricia Merdy, et al. PDMPO: a specific silicon or silica, pH sensitive fluorescent probe? RSC Adv. 2020 Aug 21;10 (51) :31003-31011.