INDY

INDY is a potent and ATP-competitive Dyrk1A and Dyrk1B inhibitor with IC50s of 0.24 μM and 0.23 μM, respectively. INDY binds in the ATP pocket of the enzyme and has a Ki value of 0.18 μM for Dyrk1A. INDY sharply reduces the self-renewal capacity of normal and tumorigenic cells in primary Glioblastoma (GBM) cell lines and neural progenitor cells[1][2].

Product Specifications

CAS Number

[1169755-45-6]

UNSPSC

12352005

Target

DYRK

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/indy.html

Purity

99.32

Solubility

DMSO : ≥ 33.33 mg/mL

Smiles

CC(/C=C1SC2=CC=C(O)C=C2N\1CC)=O

Molecular Formula

C12H13NO2S

Molecular Weight

235.30

References & Citations

[1]Ogawa Y, et al. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nat Commun. 2010 Oct 5;1:86.|[2]Pozo N, et al. Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastomagrowth. J Clin Invest. 2013 Jun;123 (6) :2475-87.