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Triptonide (Standard)

Triptonide (Standard) is the analytical standard of Triptonide. This product is intended for research and analytical applications. Triptonide (NSC 165677) is a natural product identified in Tripterygium wilfordii Hook F.. Triptonide is a Wnt signaling inhibitor with an IC50 of appropriately 0.3 nM. Triptonide has immunosuppression, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects[1][2].

Product Specifications

CAS Number

38647-11-9

Product Name Alternative

NSC 165677 (Standard) ; PG 492 (Standard)

UNSPSC

12352005

Target

Apoptosis; Autophagy; Reference Standards; Wnt; β-catenin

Type

Reference Standards

Related Pathways

Apoptosis; Autophagy; Others; Stem Cell/Wnt

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/triptonide-standard.html

Smiles

O=C([C@@]1([C@H]2O1)C(C)C)[C@]34O[C@H]3C[C@@]([H])(C5=C(CC6)C(OC5)=O)[C@@]6(C)[C@]47[C@H]2O7

Molecular Formula

C20H22O6

Molecular Weight

358.39

References & Citations

[1]Jessica Chinison, et al. Triptonide Effectively Inhibits Wnt/β-Catenin Signaling via C-terminal Transactivation Domain of β-catenin. Sci Rep. 2016; 6: 32779.|[2]Ping Yang, et al. Triptonide acts as a novel potent anti-lymphoma agent with low toxicity mainly through inhibition of proto-oncogene Lyn transcription and suppression of Lyn signal pathway. Toxicol LettPing Yang. 2017 Aug 15;278:9-17.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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