IQ-1S (free acid)
Product Specifications
UNSPSC Description
IQ-1S free acid is a prospective inhibitor of NF-κB/activating protein 1 (AP-1) activity with an IC50 of 2.3±0.41 μM. IQ-1S free acid has binding affinity (Kd values) in the nanomolar range for all three JNKs with Kds of 100 nM, 240 nM, and 360 nM for JNK3, JNK1, and JNK2, respectively.
Target Antigen
JNK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/IQ-1S-free-acid.html
Purity
99.28
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
O/N=C1C2=C(C3=NC4=CC=CC=C4N=C3\1)C=CC=C2
Molecular Weight
247.25
References & Citations
[1]Schepetkin IA, et al. Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol Pharmacol. 2012 Jun;81(6):832-45.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100233/IQ-1S-free-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100233/IQ-1S-free-acid-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
23146-22-7
Available Sizes
Curated Selection
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