IQ-1S (free acid)

IQ-1S free acid is a prospective inhibitor of NF-κB/activating protein 1 (AP-1) activity with an IC50 of 2.3±0.41 μM. IQ-1S free acid has binding affinity (Kd values) in the nanomolar range for all three JNKs with Kds of 100 nM, 240 nM, and 360 nM for JNK3, JNK1, and JNK2, respectively.

Product Specifications

CAS Number

[23146-22-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

JNK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/IQ-1S-free-acid.html

Purity

99.28

Solubility

DMSO : 16.67 mg/mL (ultrasonic)

Smiles

O/N=C1C2=C(C3=NC4=CC=CC=C4N=C3\1)C=CC=C2

Molecular Formula

C15H9N3O

Molecular Weight

247.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Schepetkin IA, et al. Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol Pharmacol. 2012 Jun;81 (6) :832-45.