SAR407899 (hydrochloride)
SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively.
Product Specifications
CAS Number
923262-96-8
UNSPSC
12352005
Hazard Statement
H361
Target
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/SAR407899-hydrochloride.html
Purity
99.14
Solubility
DMSO : 25 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(NC=C1)C(C1=C2)=CC=C2OC3CCNCC3.[H]Cl
Molecular Formula
C14H17ClN2O2
Molecular Weight
280.75
Precautions
H361
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
ROCK1; ROCK2
Citation 01
JCI Insight. 2018 Jun 7;3 (11) . pii: 98921.|Science. 2017 Dec 1;358 (6367) :eaan4368.|Adv Sci (Weinh) . 2025 May;12 (17) :e2409870.
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