SAR407899 (hydrochloride)

SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively.

Product Specifications

CAS Number

[923262-96-8]

UNSPSC

12352005

Hazard Statement

H361

Target

ROCK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/SAR407899-hydrochloride.html

Purity

99.14

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(NC=C1)C(C1=C2)=CC=C2OC3CCNCC3.[H]Cl

Molecular Formula

C14H17ClN2O2

Molecular Weight

280.75

Precautions

H361

References & Citations

[1]L?hn M, et al. Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor. Hypertension. 2009 Sep;54 (3) :676-83.|[2]Guagnini F, et al. Erectile properties of the Rho-kinase inhibitor SAR407899 in diabetic animals and human isolated corpora cavernosa. J Transl Med. 2012 Mar 23;10:59.|[3]Chen W, et al. Screening RhoA/ROCK inhibitors for the ability to prevent chronic rejection of mouse cardiac allografts.Transpl Immunol. 2018 Jun 6. pii: S0966-3274 (18) 30029-7.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

ROCK1; ROCK2

Citation 01

JCI Insight. 2018 Jun 7;3 (11) . pii: 98921.|Science. 2017 Dec 1;358 (6367) :eaan4368.|Adv Sci (Weinh) . 2025 May;12 (17) :e2409870.

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