Afoxolaner
Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod[1][2].
Product Specifications
CAS Number
1093861-60-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Chloride Channel; GABA Receptor; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/afoxolaner.html
Purity
99.89
Solubility
DMSO : ≥ 250 mg/mL
Smiles
O=C(C1=C2C=CC=CC2=C(C3=NOC(C(F)(F)F)(C4=CC(C(F)(F)F)=CC(Cl)=C4)C3)C=C1)NCC(NCC(F)(F)F)=O
Molecular Formula
C26H17ClF9N3O3
Molecular Weight
625.87
Precautions
H302, H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Mite
Available Sizes
Frequently Asked Questions
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