P-Fluoro-L-phenylalanine

P-Fluoro-L-phenylalanine (4-Fluoro-L-phenylalanine) is a substrate for tyrosine hydroxylase (TH) that can be used to study the regulation of that enzyme. p-Fluoro-L-phenylalanine binds to the L-leucine specific receptor of Escherichia coli (KD=0.26 μM) [1][2].

Product Specifications

CAS Number

[1132-68-9]

Product Name Alternative

4-Fluoro-L-phenylalanine

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Biochemical Assay Reagents

Type

Biochemical Assay Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/p-fluoro-l-phenylalanine.html

Purity

99.96

Solubility

H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)[C@H](CC1=CC=C(F)C=C1)N

Molecular Formula

C9H10FNO2

Molecular Weight

183.18

Precautions

H302, H315, H319, H335

References & Citations

[1]Hillas PJ, et al. A mechanism for hydroxylation by tyrosine hydroxylase based on partitioning of substituted phenylalanines. Biochemistry. 1996;35 (22) :6969-6975.|[2]Luck LA, et al. Fluorescence and 19F NMR evidence that phenylalanine, 3-L-fluorophenylalanine and 4-L-fluorophenylalanine bind to the L-leucine specific receptor of Escherichia coli. Protein Sci. 2000;9 (12) :2573-2576.