GNE-140 (racemate)

GNE-140 racemate is a racemate mixture of (R) -GNE-140 and (S) -GNE-140. GNE-140 racemate is a potent lactate dehydrogenase A (LDHA) inhibitor[1][2].

Product Specifications

CAS Number

[1802977-61-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Lactate Dehydrogenase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/GNE-140-racemate.html

Concentration

10mM

Purity

99.25

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

O=C(C1SC2=CC=CC=C2Cl)NC(C3=CSC=C3)(C4=CC=C(N5CCOCC5)C=C4)CC1=O

Molecular Formula

C25H23ClN2O3S2

Molecular Weight

499.04

Precautions

H302, H315, H319, H335

References & Citations

[1]Purkey HE, et al. Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. ACS Med Chem Lett. 2016 Aug 26;7 (10) :896-901.|[2] Ždralević M, et al. Double genetic disruption of lactate dehydrogenases A and B is required to ablate the "Warburg effect" restricting tumor growth to oxidative metabolism. J Biol Chem. 2018 Oct 12;293 (41) :15947-15961.