GNE-140 (racemate)
GNE-140 racemate is a racemate mixture of (R) -GNE-140 and (S) -GNE-140. GNE-140 racemate is a potent lactate dehydrogenase A (LDHA) inhibitor[1][2].
Product Specifications
CAS Number
1802977-61-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Lactate Dehydrogenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GNE-140-racemate.html
Concentration
10mM
Purity
99.25
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
O=C(C1SC2=CC=CC=C2Cl)NC(C3=CSC=C3)(C4=CC=C(N5CCOCC5)C=C4)CC1=O
Molecular Formula
C25H23ClN2O3S2
Molecular Weight
499.04
Precautions
H302, H315, H319, H335
References & Citations
[1]Purkey HE, et al. Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. ACS Med Chem Lett. 2016 Aug 26;7 (10) :896-901.|[2] Ždralević M, et al. Double genetic disruption of lactate dehydrogenases A and B is required to ablate the "Warburg effect" restricting tumor growth to oxidative metabolism. J Biol Chem. 2018 Oct 12;293 (41) :15947-15961.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LDHA
Available Sizes
Frequently Asked Questions
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