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ABBV-154

ABBV-154 is an anti-TNF antibody-drug conjugate (ADC). ABBV-154 is composed of the humanized antibody Adalimumab conjugated with a glucocorticoid receptor modulator (HY-137883). ABBV-154 can be used in studies of rheumatoid arthritis, Crohn's disease and polymyalgia rheumatica[1].

Product Specifications

UNSPSC

12352203

Target

Antibody-Drug Conjugates (ADCs) ; Glucocorticoid Receptor; TNF Receptor

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Apoptosis; Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/abbv-154.html

Smiles

[ABBV-154]

References & Citations

[1]Hobson AD, et al. Discovery of ABBV-154, an anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody-Drug Conjugate (iADC) . J Med Chem. 2023 Sep 14;66 (17) :12544-12558.

Shipping Conditions

Room temperature

Scientific Category

ADC Related

Clinical Information

Phase 2

Available Sizes

Frequently Asked Questions

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