3'OMe-m7GpppAmpG (ammonium) solution (100mM)

3'OMe-m7GpppAmpG ammonium solution (100mM) is a trinucleotide Cap analogue. 3'OMe-m7GpppAmpG ammonium shows a significant translational efficiency. 3'OMe-m7GpppAmpG ammonium can be used as a potential molecular biology tool in the field of mRNA vaccines and mRNA transfection, such as protein production, gene therapy and anti-cancer immunization[1].

Product Specifications

Product Name Alternative

M7 (3'OMeG) (5') ppp (5') (2'OMeA) pG ammonium solution (100mM)

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/3-ome-m7gpppampg-ammonium.html

Concentration

100 mM * 10 μL in Water

Purity

98.24

Solubility

10 mM in DMSO

Smiles

O[C@@H]1[C@H](OC)[C@@H](COP(OP(OP(OC[C@@H]2[C@@H](OP([O-])(OC[C@@H]3[C@@H](O)[C@@H](O)[C@H](N4C(N=C(N)NC5=O)=C5N=C4)O3)=O)[C@@H](OC)[C@H](N6C(N=CN=C7N)=C7N=C6)O2)(O)=O)(O)=O)(O)=O)O[C@H]1N8C(N=C(N)NC9=O)=C9[N+](C)=C8.[x].N

Molecular Formula

C33H45N15O24P4.xNH3

References & Citations

[1]Senthilvelan A, et al. Trinucleotide Cap Analogue Bearing a Locked Nucleic Acid Moiety: Synthesis, mRNA Modification, and Translation for Therapeutic Applications. Org Lett. 2021 Jun 4;23 (11) :4133-4136.