Dapitant
Dapitant (RPR 100893) is a non-peptide Substance P antagonist with high affinity for the human NK1 receptor. It belongs to the 7,7,4-trimethylperhydroisoindole class of compounds. Dapitant inhibits the binding of Substance P to NK1 receptors, thereby blocking its neurokinin-mediated effects. This novel antagonist represents a potential therapeutic option for conditions involving Substance P, such as neurogenic inflammation and pain modulation[1].
Product Specifications
CAS Number
153438-49-4
Product Name Alternative
RPR 100893
UNSPSC
12352005
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dapitant.html
Smiles
COC1=CC=CC=C1[C@]2(O)CCC(C3=CC=CC=C3)(C4=CC=CC=C4)[C@]5([H])[C@@]2([H])CN(C([C@@H](C)C6=C(OC)C=CC=C6)=O)C5
Molecular Formula
C37H39NO4
Molecular Weight
561.71
References & Citations
[1]SYNTHESIS OF RPR 100893, PROTOTYPE OF A NEW SERIES OF POTENT AND SELECTIVE NON PEPTIDE NKl ANTAGONISTS : THE TRIARYLPERHYDROISOINDOLOLOLS
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
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